Germ-Cell Aplasia

Germ-cell aplasia, also known as Sertoli-cell Only Syndrome (SCO), is an extremely rare but serious male infertility condition. In the United States, approximately 10 percent of couples struggle with fertility problems; only one-third of these cases result from pure male factor infertility, and only 5 to10 percent of these are caused by SCO.

Germ-Cell Aplasia Diagnosis

Because this male fertility condition is so rare, tests for SCO are performed multiple times and carefully screened by specialists. Diagnosing germ-cell aplasia is done only after several testicular biopsies have been completed.

A diagnosis of germ-cell aplasia means that the semen lacks the germ cells which lead to the creation of sperm and is azoospermic (devoid of sperm cells). While there are no studies that have conclusively shown the causes of germ-cell aplasia, researchers believe that gonadotropin deficiency, hormonal therapy, irradiation, chemicals, and environmental toxins may be potential causes.

Germ-Cell Aplasia Fertility Treatment

In the majority of SCO cases, male fertility is impossible. However, there has been some advancement in male infertility solutions for men suffering from germ-cell aplasia. If a testicular biopsy reveals that there is a small amount of sperm present in patches of the testes, a specialist can extract them for in vitro fertilization (IVF) or artificial insemination.

Find a Fertility Doctor

While the majority of men who suffer from germ-cell aplasia cannot be treated, advances in infertility treatment continue to provide couples trying to get pregnant with additional options. Meet with a qualified fertility specialist to learn more about your treatment options.